近年来，有关二甲双胍作用机制的研究层出不穷；其中腺苷酸活化蛋白激酶（AMPK）信号通路在二甲双胍的作用机制中扮演至关重要的角色。本期 ...

这一过程涉及AMPK（AMP活化蛋白激酶）的作用，它作为一种敏锐的能量传感器，在血糖水平下降时迅速响应并调节细胞内的能量平衡。 02 为了深入 ...

The close correlation between AMPK activity and glucose transport suggests that these metabolic stressors use the same AMPK-dependent signaling pathway leading to accelerated glucose transport ...

What’s the secret behind calorie restriction’s health benefits? Meet LCA, a powerful molecule improving energy, muscle health ...

In tests conducted on liver, muscle, and fat cell models, HPH-15 activated AMPK, facilitated glucose uptake, and promoted the membrane translocation of GLUT4 proteins—key processes in blood ...

The researchers also observed that LCA introduction increased the mean lifespan of nematodes from 22 to 27 days and of flies by four to five days. The administration of “upregulated metabolite LCA ...

Figure 2. Entosis is induced by long-term starvation. (A) Short-term starvation for glucose induces AMPK-dependent autophagy and nutrient recycling (left). Long-term glucose starvation induces ...

Some drugs can activate AMPK, most prominently metformin, which is approved for diabetes and being trialed in dementia. Less well-known is aldometanib, developed by Lin’s team, which blocks aldolase, ...