AMPK signaling promotes an increase in cell stiffness that drives entotic ingestion into winners (Fig. 2). AMPK signaling is also well known to activate the nutrient recycling mechanism autophagy. We ...
What’s the secret behind calorie restriction’s health benefits? Meet LCA, a powerful molecule improving energy, muscle health ...
Some drugs can activate AMPK, most prominently metformin, which is approved for diabetes and being trialed in dementia. Less well-known is aldometanib, developed by Lin’s team, which blocks aldolase, ...
That led them to conduct a second study to learn more about how LCA activates AMPK. They found that activation was dependent on signaling from certain members of the enzyme family called sirtuins.
12月18日Nature的研究报道“Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing”,聚焦于LCA通过溶酶体信号通路(lysosomal signaling pathway ...