Compounds that enhance enzyme activity show promise for cellular rejuvenation and treating age-related diseases. However, ...

Allosteric effectors that are not competitive can serve as effective activators of weak enzymes or as inhibitors of overactive enzymes. Allosteric activators or inhibitors induce small ...

Enzyme activity is tightly regulated in living organisms to maintain homeostasis and respond to changing conditions. Enzymes can be regulated by various means, such as allosteric regulation (binding ...

Owing to complete inhibition of enzyme activity ... with Phe196 in UCR2 are key for PDE4D selectivity. Although such allosteric modulators only partially inhibit PDE4 activity, they are still ...

Our work encompasses a broad range of molecular mechanisms of action, spanning covalent inhibitors, allosteric inhibitors, enzyme activators, protein (or protein complex) stabilizers, and protein ...

Notably, SIRT3, the major mitochondrial sirtuin enzyme, plays a critical role in determining health span and lifespan through its regulation of mitochondria—the cellular powerhouses that decline with ...

The ACCs are highly regulated by both allosteric and covalent modifications ... The animal FAS is another remarkable multifunctional enzyme; it contains seven catalytic activities plus a site for the ...