Amitriptyline is part of a group of ... It can also be used to treat episodic cluster headaches. For migraine prevention, the first dose is a onetime higher dose of 240 milligrams (mg).

Preventive antimigraine therapy (PAM) should probably not be considered until the headache frequency exceeds ... 1 studies for PAM – propranolol, amitriptyline, topiramate, valproate and gabapentin.