Physiological roles of cell competition in vertebrates and the universal mechanisms regulating diverse cell competition are unknown. Here, authors show that Foxo3-mediated physiological cell ...

A variety of factors can trigger cell death in a tissue. For example, the process of apoptosis, or programmed cell death, selectively removes damaged cells — including those with DNA damage or ...

and thereby steer the direction of cell migration. (6) Mitochondria-associated membranes (MAMs), the contact sites between mitochondria and ER, are a central hub for Ca2+ signaling, apoptosis ...

During islet development, beta-cell death, rather than proliferation alone, regulates beta-cell mass and shapes the immune ...