Both aspirin and ibuprofen inhibit COX-1 and COX-2, but acetaminophen appears to inhibit only COX-3. Very recently, additional anti-inflammatory agents have been introduced, ones that inhibit COX ...

Both beneficial and adverse effects are due to the same mechanism of action, which is inhibition of COX-dependent ... PPI); if aspirin is indicated, naproxen + PPI and aspirin, given 2 h before ...