These vesicles were shown to contain fragments ... Because p62, one of the adaptors involved in directing substrates for autophagic degradation, has a ubiquitin-binding domain, researchers focused ...

Autophagy (= "self-eating") is a vesicle-mediated cellular process of protein and organelle degradation. Autophagy enables cell survival during nutrient starvation and also plays a role in ...

Voltage-gated calcium channels cannot form properly when cacophony is mutated, preventing fusion of the synaptic vesicle with the plasma membrane and neurotransmitter release. “We were surprised to ...