As early as 1975, the triad of GI mucosal injury, presence of bacteria in the gut, and introduction of a metabolic substrate (eg, feedings) was proposed as the etiology of bowel necrosis [3] (Fig 2).

Infliximab is a chimeric monoclonal antibody against tumour-necrosis factor-α (TNF-α ... Targan, M.D., Director, at the Cedars-Sinai Inflammatory Bowel Disease Center, UCLA School of Medicine ...

In addition, magnetic resonance imaging (MRI) may be used. [44] Early imaging and diagnosis are warranted because bowel necrosis can occur rapidly. Minimal delay in treatment is key, and early ...

More information: Tom Thomas et al, A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory ...

Patients with active IBD have elevated proinflammatory cytokines, including tumor necrosis factor (TNF)-α ... diseases ...