Both aspirin and ibuprofen inhibit COX-1 and COX-2, but acetaminophen appears ... to make yet more specific drugs tailored to each prostaglandin action. One day we may use one drug to dull pain ...

Table 1. Example of the range of IC 50 values (µM) generated for individual NSAIDs using a variety of in vitro assay systems. NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was ...

through COX inhibition, becomes an important clinical issue. This paper reviews some of these cardiovascular issues, including blood pressure and potential thrombotic effects of prostaglandin ...

In pain-control centers of the brain and spinal cord — the central nervous system (CNS) — the drug lowers prostaglandin ...