Aim: The present study aimed to investigate the human genetic diversity of the CYP450 superfamily in order to identify functional interethnic differences and analyze the role of CYP450 enzymes in ...
A number of studies have highlighted that ethnicity is an important factor influencing the genetic variability of some CYP450 enzymes and that human adaptation could have a role in shaping the ...
By contrast, warfarin is metabolized by multiple enzymes in the CYP450 system, making it susceptible to drug–drug and drug–food interactions, and meaning that it produces highly variable ...