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腾讯网
15 天
浙大二院钱文斌/杭州一院王世兵团队研究设计新型靶向CD47工程化溶 ...
其修饰有高亲和力的抗CD47纳米抗体(αCD47nb),该纳米抗体是重链单克隆抗体的最小抗原结合结构域(VHH),并结合肿瘤细胞表面CD47。通过体外 ...
腾讯网
28 天
宜明昂科:PD-L1/VEGF+CD47“三靶”联用临床研究申请 (IND)获NMPA受理
与公司其他基于CD47的双特异性分子具有类似的结构。IMM4701具有稳健的抗肿瘤活性,在多种实体瘤模型中,IMM4701在3.0 mg/kg(~0.3 mg/kg人体等效剂量 ...
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