we report that alterations in FAT1 are selected early during lung cancer evolution and cause chromosomal instability and whole-genome doubling. Persistent DNA lesions can occur throughout the ...

A study identified the mutation mechanism LTA chromothripsis in 50% of high-grade osteosarcoma cases, explaining its genomic ...

Reactive oxygen species (ROS) from mitochondria are key drivers of genetic chaos in cancer by causing the collapse of micronuclear envelopes, a process that fuels the chromosomal instability (CIN ...

Loss of the Y chromosome (LOY) in men, a dynamic mutation linked to aging, impairs immune function and increases risks of ...