We are interested in the mechanism of chromosome replication, a process that is highly conserved across eukaryotes and that involves the duplication of both the chromosomal DNA and its associated ...

The new finding is published in Cell in an article titled, “ SMC motor proteins extrude DNA asymmetrically and can switch directions ,” and is key to understanding how these motors shape our genome ...

Research in my laboratory centers on: (i) the events that occur when the replisome (the multi-component enzyme machine that replicates chromosomal DNA) encounters blockages to replication fork ...

Chromosome Dynamics: Although genetic information is encoded in a one-dimensional array of DNA bases, all major DNA processes (replication, transcription and recombination) are controlled by changes ...

Each cell with a nucleus contains chromosomes, which are made from DNA Human body cells each contain 23 pairs of chromosomes, half of which are from each parent. So, human gametes (eggs and sperm ...

A single strand of DNA forms a chromosome, like the one displayed to the left. This chromosome is magnified (1000x). That's not nearly enough to show a single strand of DNA, which is only wide ...

The nucleus of each human body cell contains 46 chromosomes. Each chromosome contains about 1000 genes. There is enough DNA in all the cells in a human body to stretch to the sun and back again ...

This experiment showed that the biochemical machinery involved in telomere replication had to be very broadly conserved, and opened the door to studies of telomere biochemistry and genetics in yeast ...

In sexual reproduction—the way most life-forms procreate—each parent provides half an offspring’s chromosomes ... been preserved by the identical replication—essentially, cloning ...