Oral administration of the vasopressin V2-receptor antagonist tolvaptan is safe and effective for the treatment of chronic hyponatremia in the long term, according to the results of the SALTWATER ...

Verbalis et al. induced chronic hyponatremia in rats fed a liquid diet by administration of the vasopressin V2 receptor agonist desmopressin for a period of 3 months. Hyponatremia was associated ...