COX-2 is involved in prostaglandin synthesis and expressed ... may be another important player in neural aspects of the inflammatory response. Figure 1: Regulatory checkpoints of peripheral ...

IC 50 values provide no indication of the mechanism of enzyme inhibition ... (defining both K i values and rate constants) of COX-1 and COX-2 need to be conducted as a first step prior to ...

NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in making prostaglandins. By blocking the Cox ...

Unlike COX-1, COX-2 is an inducible enzyme that is not normally present in the eye. COX-2 produces prostanoids that function primarily during defined stages of cellular development or pathological ...