All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...

or in the the APC or APPROVE trials. Controversy about the mechanisms of potential cardiovascular side effects of COX inhibitors and NSAIDs persists. Intriguingly, the sulfone COX2 inhibitors ...