A meaningful rank of NSAIDs in terms of inhibition of COX should take into account the complexities inherent in biochemical systems, including the mechanism of catalysis of the endogenous substrate.

[21] However, the ranking of NSAIDs as inhibitors of COX and interpretation of rank orders to inform evidence of clinical toxicity has continued unabated. As would be anticipated with the ...

The idea seems plausible on its face. COX inhibitors seem to affect sexual behavior by blocking downstream effects of testosterone, which is known to masculinize the developing brain through ...