A meaningful rank of NSAIDs in terms of inhibition of COX should take into account the complexities inherent in biochemical systems, including the mechanism of catalysis of the endogenous substrate.

"Very lame and imperfect theories are sufficient to suggest useful experiments which serve to correct those theories and give birth to others more perfect. These, then occasion farther experiments ...

The idea seems plausible on its face. COX inhibitors seem to affect sexual behavior by blocking downstream effects of testosterone, which is known to masculinize the developing brain through ...