Cyclin-dependent kinases (CDKs ... on the basis of similarities in sequence and function as described below. This nomenclature will facilitate the rational and comparative study of the poorly ...

Here we identify indirubin and its analogues as potent inhibitors of cyclin-dependent kinases ... peaks for G1 and G2 cells and of a polynomial function broadened by gaussian variability for ...

The Branin, or Branin-Hoo, function has three global minima. The recommended values of a, b, c, r, s and t are: a = 1, b = 5.1 ⁄ (4π 2), c = 5 ⁄ π, r = 6, s ...

The 4-dimensional Hartmann function is multimodal. It is given here in the form of Picheny et al ... Picheny, V., Wagner, T., & Ginsbourger, D. (2012). A benchmark of kriging-based infill criteria for ...

Authors should provide at the time of submission a short paragraph explaining why their work justifies urgent publication as a Communication. Ideally, a Full paper in Food & Function should follow ...

Malignant cells down-regulate cell death by overexpressing a transcription factor called BCL6. “Our idea was to borrow a little bit of the activity of the kinase and drag it over to where BCL6 is ...

Some proteins in the human body are easy to block with a drug; they have an obvious spot in their structure where a drug can ...

In this issue, Papismadov et al (2024) report that p21 (CDKN1A), known to activate the senescence growth arrest, also ...

Executive function describes a set of cognitive processes and mental skills that help an individual plan, monitor, and successfully execute their goals. The “executive functions,” as they’re ...

CID-078, Circle Pharma’s first-and-only-in-class cyclin A/B RxL inhibitor, demonstrated single-agent tumor regressions in both small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC ...

A function is a way of describing what happens to an input variable, in order to get the output result. \(\text{Input} \rightarrow \text{FUNCTION} \rightarrow \text{Output}\) If we think of a ...

Program for Cancer and Cell Biology, Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences; Peking University International Cancer Institute; and State Key Laboratory ...