It is now known that all of these drugs block the activities of cyclooxygenase (COX), enzymes that act early in the pathways of prostaglandin synthesis. So far, three COX enyzymes have been ...

Although aspirin has been widely used for a long time, its molecular target—an enzyme called cyclooxygenase (COX)—was only identified in the 1970s. Cyclooxygenase catalyzes the first step of ...

Common brand names for ibuprofen include Motrin and Advil. It works by blocking the enzyme cyclooxygenase (COX), which plays ...

"Ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) work by inhibiting cyclooxygenase enzymes, COX-1 and COX-2, which are used by the body to make signaling molecules called ...

In addition, progression of small adenomas to large highly dysplastic adenomas before they ultimately develop into carcinomas is associated with high expression of the cyclooxygenase enzyme COX-2, ...

NSAIDs are now classified by their ability to inhibit COX enzymes rather than by their chemical structure, although the notion of COX-2 selectivity was somewhat discredited by a confusing ...

Important considerations when investigating NSAID inhibition of COX in vitroare the source of the enzyme, the Michaelis constant (K m)of the endogenous substrate arachidonic acid, the mechanism of ...