so histones bind with DNA very tightly. The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA ...

In a groundbreaking study, scientists have discovered a way to manipulate the very fabric of life by using light to reshape ...

DNA has to be carefully packaged and organized in cells so it will both physically fit into the nucleus, but will also remain ...

GET, a novel computational model, accurately predicts gene activity by analyzing chromatin accessibility and DNA sequences ...

In eukaryotes, genomic DNA is stored in the nucleus as nucleosomes, interacting with a set of proteins, forming a molecular complex called chromatin. The proper folding of the chromatin structure ...

To fit such a long molecule within the tiny space of the nucleus, DNA bends and loops in several ways. The largest of these loops results from the helical coiling of chromatin (the thick line in ...

This important study reveals a role for IκBα in the regulation of embryonic stem cell pluripotency. The solid data in mouse embryonic stem cells include separation of function mutations in IκBα to ...

Caltech researchers have developed a new method to map the positions of hundreds of DNA-associated proteins within cell nuclei all at the same time. The method, called ChIP–DIP (Chromatin ...

The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on ...

Epigenetic regulation relies on the dynamic modification of the two building blocks of chromatin: DNA and histone packaging proteins, to establish and maintain cell identity and fate. We develop and ...