Nicks are potentially deleterious DNA lesions that, if not corrected, may give rise to lethal double-strand breaks. Accordingly, the total loss of DNA ligase function is lethal. DNA ligases catalyze ...

They function in vivo to repair a break in E ... The N-terminal ATP-dependent ligase domain belongs to the covalent nucleotidyltransferase enzyme superfamily that includes classic RNA/DNA ligases and ...

This process is essential for DNA replication ... indicates that this function of Cks1 is independent of CDKs and links Cks1 with the Skp2 subunit of the SCF ubiquitin ligase.