Nicks are potentially deleterious DNA lesions that, if not corrected, may give rise to lethal double-strand breaks. Accordingly, the total loss of DNA ligase function is lethal. DNA ligases catalyze ...

Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity ... for DNA-damage-induced ...

This process is essential for DNA replication ... indicates that this function of Cks1 is independent of CDKs and links Cks1 with the Skp2 subunit of the SCF ubiquitin ligase.