DNA’s iconic double helix has long been the symbol of life’s blueprint. However, the human genome conceals far more ...

Promoter sequences are DNA sequences that define where transcription of a gene by RNA polymerase begins. Promoter sequences are typically located directly upstream or at the 5' end of the ...

The genome contains tens of thousands of genes. Like a gigantic orchestra, their interaction is the basis for all vital ...

DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a ...

A groundbreaking study in Nature Genetics, led by Martin Fischer, laboratory head, and Steve Hoffmann, research group leader ...

The epigenetic modification, DNA methylation, is characterized by 5-methylcytosine (5-mC) and found in specific genomic ...

Comparison of insulin promoters spanning 450 million years of ... is not limited to the consensus sequences as the flanking regions also contribute to ECRs. This is true of regulatory elements ...