Alternative splicing increases protein diversity by allowing multiple, sometimes functionally distinct, proteins to be encoded by the same gene. It can be specific to tissues, stress conditions ...

where cells trim away the non-essential portions Recognizing splice sites is a crucial step in assembling gene transcripts to identify the functional parts of DNA and the roles they play in the body ...

Cells rely on genes to guide their functions, with each gene containing both useful instructions (called exons) and non-essential segments (called introns). Splicing is the process by which cells ...

According to the researchers, recognizing splice sites computationally is a crucial step in accurately assembling gene transcripts in modern genetics studies, where RNA sequencing experiments ...

Johns Hopkins researchers have developed a powerful new AI tool called Splam that can identify where splicing occurs in genes—an advance that could ...

This study provides important insights into the regulation of a retained intron in the mRNA coding for OGT, a process known to be regulated by the O-GlcNAc cycling system, and highlights the ...

Alternative splicing is crucial for eukaryotic gene expression and influences protein function and regulation, with mis-splicing linked to numerous diseases. In this webinar, Dr. Megan L Noonan will ...

Vigeneron GmbH has received IND approval from the FDA for VG-801, a novel mRNA trans-splicing gene therapy to treat Stargardt disease and other retinal dystrophies associated with mutations in the ...