Whether it is a microbe, a rose, or a dolphin, any form of life gets its building and operating instructions from the molecule of life, DNA. DNA comprises ... known as messenger RNA, makes a ...

During DNA replication, the complementary base pairing ensures faithful copying of the genetic material. In RNA, cytosine also pairs with guanine. However, RNA is typically single-stranded and serves ...

This important theoretical study examines the possibility of encoding genomic information in a collective of short overlapping strands (e.g., the Virtual Circular Genome (VCG) model). The study ...

The primase produces a very short RNA molecule (an RNA primer ... other proteins (not shown) are needed for DNA replication. These include a set of initiator proteins to begin each new replication ...

Telomerase binds to the G-tail of the telomere through the RNA template ... Then, during the next round of DNA replication, DNA polymerase and the DNA repair enzymes fill in the other strand.

DNA achieves this feat of storing, coding and transferring biological information though its unique structure. Replication of DNA DNA replication is the process by which a cell makes an identical ...

These drugs interfere with DNA synthesis and replication, leading to the death of rapidly dividing ... Their importance extends beyond their role in DNA and RNA, as pyrimidines and their derivatives ...

An analogous process occurs during chromosomal DNA replication, whereby the 5’-RNA segments that prime discontinuous synthesis of Okazaki fragments are excised, and the intervening gaps are filled in ...

They started with a fold found in DNA and RNA polymerases—enzymes responsible for genome replication and gene transcription.

By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...

Multistep loading of a DNA sliding clamp onto DNA by replication factor C ... Mobile origin-licensing factors confer resistance to conflicts with RNA polymerase. Cell Rep. 2022 Mar 22;38(12):110531.

including DNA replication and repair, mRNA maturation, and pre-rRNA processing. To safeguard DNA and RNA from nonspecific cleavage by these molecular scissors, our cells support elegant mechanisms of ...