It was 1961. Anfinsen 1 had shown that the correct disulfide bonds of ribonuclease A (RNaseA) form spontaneously upon oxidation in air, driven by the free energy of folding. The central dogma of m ...

Once transported there, the LacZ enzyme undergoes oxidation through disulfide bond formation, thus deactivating it. Therefore, problems in either transportation or disulfide bond formation would ...

Once transported there, the LacZ enzyme undergoes oxidation through disulfide bond formation, thus deactivating it. Therefore, problems in either transportation or disulfide bond formation would ...

Disulfide bonds (RS-SR) are more stable than peroxide ... Sulfur can adopt a wider variety of oxidation states than oxygen, for instance in the oxidation of cysteine to sulfenic (R-SOH), sulfinic ...

Once there, the LacZ enzyme is deactivated by oxidation caused by the formation of disulfide bonds. Therefore, an abnormally activated LacZ enzyme would result from issues with either ...