Instead of the enzyme mechanism described in biochemistry text-books, hen lysozyme hydrolysis was postulated to occur by a ring-opening mechanism based on substrate interactions defined by the active ...

The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions. My research integrates diverse experimental approaches ...

This allows us to study chromatin biology with proteoform level specificity and observe quantitative changes to reveal mechanisms of disease. Our laboratory works at the intersection of three ...

FMI researchers have developed a new tool that maps how proteases—enzymes ... Grosshans lab at the FMI have created a new technique, named qPISA—or "quantitative Protease specificity Inference ...

The way that plants process nutrients has a rich back story—they rely on enzymes that ... Genomics and Systems Biology Division of Lawrence Berkeley National Laboratory (Berkeley Lab).