The behavior of a person's genes doesn't just depend on the genes' DNA sequence - it's also affected by so-called epigenetic factors. Changes in these factors can play a critical role in disease.

Research reveals that frequent high-potency cannabis use alters DNA methylation, affecting mitochondrial and immune genes, ...

The central dogma proposed that genetic information predominantly transfers from DNA to RNA during gene expression to make a functional product protein. This absolute theory has been debunked ... of ...

such as protein degraders (PROTACs) and antibody-drug conjugates, to enhance the effectiveness and reduce the side effects of epigenetic inhibitors. Strategies involving CRISPR/Cas9 and ...

The Luo Lab is interested in developing and leveraging novel approaches at the interface of chemistry and biology to annotate functional roles of epigenetic modulators. Epigenetic regulation is ...

Epicrispr Biotechnologies, a leading epigenetic editing company, presented new data on its hypercompact platform for ...

Epigenetics affects gene activity, or expression ... By regulating the flow of RNA polymerase II – a protein complex that reads and decodes DNA – H3K4me3 determines when gene expression should start ...

Six epigenetic features define the new Epigenetic Hallmarks of Cancer, an add-on to the widely accepted Hallmarks of Cancer. Scientists concluded that malignant transformation requires some degree ...

Bryan Johnson, a tech entrepreneur and age reversal enthusiast, has just undergone a groundbreaking procedure called Total ...

Meet 10 of our spinouts, all committed to changing the story of cancer. Astex's FBDD approach has led to the approval of ...

Their work revealed how the epigenetic landscape influences transcription factor binding. Problems with transcription have been implicated in numerous cancers, so this more detailed understanding ...

2020 Jun 3;142(22):9999-10007. doi: 10.1021/jacs.0c01325. Epub 2020 May 22. Zheng Q, Maksimovic I, Upad A, David Y. Non-enzymatic covalent modifications: a new link between metabolism and epigenetics.