AML originates from a rare population of cells, termed leukemic stem cells (LSCs) or leukemia-initiating cells, which are capable of self-renewal, proliferation and differentiation into malignant ...

AML = Acute myeloid leukemia; CK = Complex karyotype; ECOG = Eastern Cooperative Oncology Group; EORTC = European Organization for Research and Treatment of Cancer; GIMEMA = Italian Group for ...

Socioeconomic factors, particularly education level, significantly impact access to allo-HCT for AML patients, with lower education reducing transplant likelihood by 30%. Reliance on government ...

More information: Ali Bazarbachi et al, Improvements in Posttransplant Outcomes Over Two Decades in Older Patients with Acute ...

HUHS015 disturbs ALKBH3 functioning as prostate cancer antigen 1. c. R-2HG prevents FTO removing m6A from MYC/CEBPα in AML. d. WBSCR22 knockdown enhances the sensitivity of colorectal cancer ...

Equally important, the approach did not damage healthy early blood stem cells or immune cells in human tissue or AML mouse models. When leukemia invades the bone marrow, it produces abnormal early ...