To better understand mechanisms of GPCR activation, this information must be complemented ... the human A2A adenosine receptor (A2AAR), where NMR uncovers the role of a key allosteric center in ...

Septerna aims to find drugs that modulate GPCRs via allosteric sites, testing the approach across endocrine, CNS, inflammatory and metabolic diseases. Septerna has raised nearly US$500 million ...

GPCRs are a fertile source of drug targets ... Septerna is also developing SEP-631, billed as an MRGPRX2 negative allosteric modulator for the treatment of chronic spontaneous urticaria (CSU ...

Exicure, Inc. (Nasdaq: XCUR, “Exicure”, “the Company”), has announced the signing of a Memorandum of Understanding (MOU) with GPCR Therapeutics, Inc. (“GPCR ...

CHICAGO, December 27, 2024--(BUSINESS WIRE)--Exicure, Inc. (Nasdaq: XCUR, "Exicure", "the Company"), has announced the signing of a Memorandum of Understanding (MOU ...