The resulting damage cannot be reversed. The term “gangrene” refers to a large area of necrosis. This article discusses the types of necrosis as well as the causes and risk factors.

WINS must be differentiated from all other causes of acute thrombosis with skin necrosis, including acute ... and Fournier's gangrene. The clinical history and cutaneous distribution may help ...

If the gangrene is caused by an infectious agent ... and a shallow open sore forms as the skin around the bite dies (necrosis). It is the only proven type of necrotic arachnidism in humans.