Human intestinal epithelial cells (hIECs) are arranged as a monolayer of cells and provide the first line of defense against invading pathogens. Upon viral infection hIECs upregulate type I and III ...

To test how RANK–RANKL signalling directly affects intestinal epithelial cells, we exposed mouse and human intestinal organoids (self-organized 3D tissues derived from intestine-resident stem ...

The gastrointestinal epithelium is rapidly renewed during normal homeostasis and regenerated after damage, requiring remarkable proliferative capacity and dynamic regulation of stem cells. We are ...

Cell competition in epithelial tissue eliminates transformed cells expressing activated oncoproteins to maintain epithelial homeostasis. Although the process is now understood to be of mechanochemical ...

These cultures are derived from stem cells isolated from human intestinal tissue. The stem cells are propagated in vitro and form mature intestinal epithelium upon growth factor manipulation. In order ...

Antidepressants known as selective serotonin reuptake inhibitors, or SSRIs have been the first line of treatment for mood disorders and anxiety for the last three decades. These medicines mainly ...

During pregnancy, the breasts expand, resting heart rate speeds up, and organs shift to accommodate the growing fetus. And now, scientists have added one more item to this list: the gut grows ...

The gastrointestinal tract is a complex ... and gene expression are altered in disease states. Focusing on epithelial metaplasia, the researchers conducted trajectory analysis to trace the ...