Lipid nanoparticles deliver CRISPR tools directly to lung stem cells, offering new therapeutic avenues for treating genetic ...

For more details, take a look at C.M. Fouletier-Dilling et al. 2005, Human Gene Therapy, 16:1287–1297. Adenovirus 5 is an important vector because it can infect a variety of non-dividing cells and ...

The transcription of eGFP is driven by the IRES so the eGFP expression will be slightly less than seen in the Ad5-CMV-eGFP vector ... but no transgene. This virus is often used as a control virus in ...

No model recapitulates the human disease perfectly. By organizing information related to the phenotypic characterization of selected ALS models, this resource conveys what is known about each one and ...

Swiss-based DiNAQOR has developed a revolutionary gene therapy platform which combines gene-vector-promoter constructs ... or surgery, there is no cure for heart failure, which causes more deaths ...

Sep. 16, 2024 — CREME is a virtual laboratory that allows scientists to simulate specific decreases in gene activity. It offers a powerful new tool for identifying and understanding important ...

In examples 1 and 4 of Figure 1, we examined the target region in the parent molecule after ET recombination to determine whether it had been copied into the subclone, or excised from the parent.

and skeleton with no currently approved treatments. The findings ... Aug. 20, 2024 — A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene ...

A genetic analysis of almost half a million people has concluded there is no single "gay gene". The study, published in Science, used data from the UK Biobank and 23andMe, and found some genetic ...

The advent of large-scale sequencing in both development and disease has identified large numbers of candidate genes that may be linked to important phenotypes. Validating the function of these ...

Treatment with voretigene neparvovec involves major vitreoretinal surgery in which a bleb, or bubble, is created under the retina and the gene vector is ... is there is no other treatment, so ...

This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...