Diabetes. 2006;55(1):1-12. Glucokinase is required for GSIR in the physiological range of 4-8 mmol/l. Glucokinase is needed for amino acid and fatty acid stimulation of insulin release.

Glucokinase (GCK) is the enzyme which sensors glucose level in pancreatic beta cells. If glucose reaches the threshold of the enzyme, the pancreas releases its insulin. MODY variants (=mutations) in ...