Gan’s lab investigates how other cell death mechanisms might be exploited ... which helps in the formation of glutathione, a potent antioxidant that can counteract lipid peroxidation.
the liver's robust antioxidant defenses, including glutathione (GSH) and vitamin E, question the widespread applicability of ferroptosis as a primary mode of cell death in DILI. Mechanisms of ...
However, the liver's robust antioxidant defenses, including glutathione (GSH ... as the primary cytotoxic mechanism. These findings challenge the hypothesis that ferroptosis, characterized ...
Reasons for inhaled GSH's effectiveness include its role as a potent antioxidant ... presumed mechanisms of action and optimal doses to be administered were compiled and evaluated. Glutathione ...
Support for this hypothesis is found in the observations that high glucose concentrations increase intraislet peroxide levels, that islets contain very low levels of antioxidant enzyme activities ...