The trans-Golgi network (TGN) is an assembly of pleiomorphic tubular membranes that emanates from the trans-Golgi pole. It has multiple crucial roles in intracellular transport as a sorting node ...

引言膜蛋白是细胞生命活动中至关重要的分子，它们不仅参与物质运输、信号传导，还帮助维持细胞的结构稳定性。在多种细胞类型中，尤其是上皮细胞，膜蛋白的极性排序确保了细胞的正常功能发挥。一个典型的例子是肠道上皮细胞，它们在吸收和分泌过程中依赖于膜蛋白的极性排 ...

Membrane proteins are sorted to the plasma membrane (PM) via Golgi-dependent trafficking. However, our recent studies challenged the essentiality of Golgi in the biogenesis of specific transporters.

重症冠状病毒是否会通过调控宿主的非经典分泌系统来诱导炎症因子的分泌，引起过度炎症反应？ 2024 年 10 月 8 日，清华大学药学院张敏研究团队在 Nature Communications 期刊发表研究性论文，发现重症冠状病毒的包膜蛋白（ Env elop e, E ）是重要的致病因子，通过激活 THU 通路刺激炎症因子分泌，解释了重症冠状病毒感染导致宿主过度炎症的原因 ...

引言真核细胞的生命过程依赖于特化的细胞器。不同细胞器在功能上分工明确，但同时需要密切协作，形成细胞器互作网络。细胞器之间可通过物理接触（膜接触），实现快速的物质交换和信息交流，高效执行各项生物学功能，维持细胞及机体的功能稳态【1】。转脂蛋白在这些膜接 ...

A team of scientists supported by the National Institutes of Health (NIH)'s The BRAIN Initiative, including Davi Bock, Ph.D., ...

Freshly synthesized proteins are sent to the Golgi for additional processing and for sorting to their final destinations through a process analogous to the postal service. Delivery to the sides of ...

Golgi staining of a mouse brain done by Tao Lin of the NRI Neuropathology Core and imaged by Biochemistry student Quynh Nguyen. Quynh is studying how TMEM106B determines the balance between neuronal ...

More information: Christian de Caestecker et al, A size filter at the Golgi regulates apical membrane protein sorting, Nature Cell Biology (2024). DOI: 10.1038/s41556-024-01500-0 ...

N proteins link to RNA to help keep it stable. Additional vesicles (that come from the endoplasmic reticulum and Golgi complex) assemble spike, M and E proteins. Finally, It Breaks Out Vesicles ...