生物通1mon
APS | AlphaFold3预测GPCR-配体复合物的局限性评测：实验结构仍是关键
该文章收集了AlphaFold3（AF3）发布后的GPCR-配体复合物实验结构，并从整体结构的准确性、口袋预测能力、复合物预测能力和可变区预测效果方面全面评估了AF3在GPCR-配体复合物方面的表现 ...
生物通2y
浙江大学百人学者张海涛：Nature文章解开二十年谜题
我们解析的AT1R和AT2R两个晶体结构都是应用XFEL获得的（Cell 2015, Nature 2017）。 生物通：作为非典型GPCRs，AT2R的结构以及作用机制与一般GPCRs有何区别？与它的兄弟受体AT1R又有什么区别呢？这些 ...
Nature4y
G-Protein-Coupled Receptors, Pancreatic Islets, and Diabetes
At the interface between these circulating factors and insulin/glucagon secretion are GPCRs, which in islets mediate the effects of many of the circulating factors, such as glucagon-like peptide-1 ...
Nature2mon
The next era for GPCR-focused biopharma
“When Heptares formed, we chose to focus on GPCRs because we knew that targeting these receptors leads to drugs,” says Matt Barnes, president and head of R&D at Nxera Pharma. GPCRs are ...
Morningstar18d
Exicure, Inc. Partners with GPCR Therapeutics to Fuel New Growth in Biotech
Exicure, Inc. (Nasdaq: XCUR, “Exicure”, “the Company”), has announced the signing of a Memorandum of Understanding (MOU) with GPCR Therapeutics, Inc. (“GPCR ...