However, with this diversity, the many components associated with HTS—the bioassay, the assay format, the nature of the library, reagent and sample delivery methods, the detection ...

This broad chemical biology purview pushes the boundaries for HTS assays (Review, p. 466) and changes the demands for the composition of chemical libraries (Commentary, p. 442). Thus, HTS in ...

This session introduces basic concepts of imaging-based high-throughput screening (HTS) and high-throughput profiling assay development. Imaging-based HTS assays are designed to evaluate a discrete ...

A small molecule chemical screen can be cell-based or based on a biochemical assay. The assay developers at FIMM HTB unit set up the assay and optimize it for high throughput screening. With positive ...

Bafilomycin increased dose-dependently the FP value due to loss of packaging (fig.2). Further studies showed that this assay is suitable for HTS thanks to proper Z’ factors and to the possibility to ...

We develop fast and predictive high-throughput screening (HTS) tools, for example, by using bacterial bioreporters, and use combinations of target- and cell-based approaches in our screening campaigns ...

cGAS titration at 1 hour and 24 hours demonstrates the assay's oustanding signal stability. The signal stability seen here is crucial for HTS where the screen size can require significant more time.

However, researchers new to HTS do not often appreciate how readily this technology furnishes artefacts (Pan Assay Interference Compounds or PAINS) that can distract and mislead. Join Jonathan Baell ...