Use caution with concomitant drugs that are known to be potentially hepatotoxic (e.g., acetaminophen, antibiotics, antiepileptics). May lead to onset of new hypertension or worsening of ...

Drug-induced liver injury (DILI) is common because it can be caused by different pharmacological agents from nearly all classes of medications, including hepatotoxic drugs, anesthetics, anticancer ...

This study reports on the adverse effect profile of methotrexate when used in the treatment of RA and PsA in a district general hospital population, and looks at the effect of alcohol consumption ...

follow-up hepatic laboratory testing should be performed more frequently until the issue is resolved. If anyone taking the drug experiences signs or symptoms of liver injury, they should stop ...

Recent draft guidance highlights the challenges that industry and regulators face to predict rare drug-induced liver injury. At the end of August 2008, the consultation period ended for comments ...