Background: Variable rates of HER2 protein overexpression and gene amplification have been reported in advanced ovarian cancers (AOC). Trastuzumab, tested only as a single agent, has been shown to ...

随着乳腺癌早筛早诊的宣传和普及，早期乳腺癌的检出率也越来越高。HR+/HER2- 是乳腺癌中预后最好的亚型 [2] 。HR+/HER2- 早期乳腺癌经标准治疗后 ...

In normal amounts, HER2 plays a crucial role in epithelial cell proliferation, survival, and differentiation. HER2 overexpression is linked to aggressive tumor growth, a poorer prognosis ...

Another uses a target with high expression on tumor cells, such as HER2, for high-affinity binding with one arm. “With the other arm, one can zoom in and block a molecule such as HER3 that is ...

Cite this: The Role of Hormonal Therapy in the Management of Hormonal-Receptor-Positive Breast Cancer With Co-Expression of HER2 - Medscape - Sep 01, 2008. The article is based primarily on a ...