The book picks up where Heretics of Dune left off ... The six original Dune books cover a period of thousands of years. By the end, a lot of roads has been travelled. There is resolution, but ...
The Bene Gesserit eventually return to a position of power in Herbert’s penultimate book, Heretics of Dune. But as that book is set 1,500 years after Leto II's death, the sisters are downtrodden ...