Expert Rev Clin Pharmacol. 2010;3(3):321-329. Despite a propensity to block hERG channel function, as determined by electrophysiology, for a limited number of compounds no cardiac arrhythmias have ...

A major focus of our research is on hERG channels, which are critical to normal cardiac repolarization. Inherited mutations in the hERG channel gene, or drug-induced inhibition of channel function ...