Mammalian genomes encode eleven proteins of the classical histone deacetylase (HDAC) family. They are numbered HDAC1 to HDAC11 and can be classified into four distinct groups (class I, IIa ...
The basic building blocks of chromatin are nucleosomes, each of which is composed of 146 bp of DNA wrapped around a histone octamer that consists of two copies each of H2A, H2B, H3 and H4.
The AptaFluor SAH Methyltransferase Assay uses a highly sensitive RNA aptamer that is capable of directly detecting SAH. The sensitivity of the aptamer (measures SAH at concentrations below 10 nM ...