When Dr. Lawrence C.B. Chan and Dr. Vijay Yechoor of Baylor College of Medicine used a special gene therapy to induce the livers of mice with diabetes to make islet or beta cells, they knew they were ...

The new approach could be used to stop the body from rejecting transplanted organs and tissues, such as pancreatic islet cells, which are sometimes used to treat type 1 diabetes. That way ...

Three people with type 1 diabetes who received Vertex Pharma’s islet cell therapy VX-880 have been ... reduction of haemoglobin A1c levels – a marker of blood glucose control – to 7% or ...

Nat Clin Pract Endocrinol Metab. 2006;2(5):240-241. Diabetes occurs when there is an inadequate functional mass of insulin-producing pancreatic β cells. Replacement of β cells by islet ...

The technology uses engineered T cells that act as immune “referees” to soothe overreacting immune responses. They also can mop up inflammatory molecules without lowering the entire body’s immune ...

For these patients, a treatment called islet transplantation can help better control blood glucose by giving them both new insulin-producing cells as well as cells that prevent glucose levels from ...

This includes examining genes, the initiation and progression of islet autoimmunity through autoantibodies (markers of future risk of developing type 1 diabetes), cellular immunity and other factors ...

PDX-1 is a critically important transcription factor for the insulin promoter, is absent in glucotoxic islets, and, when transfected into glucotoxic ß-cells ... of elevated markers of oxidative ...