Case 1 suggests that ICA may be a transient marker of a persisting underlying ... indicate inevitable progression to total islet cell destruction and that cessation of immune islet cell ...

Three people with type 1 diabetes who received Vertex Pharma’s islet cell therapy VX-880 have been ... reduction of haemoglobin A1c levels – a marker of blood glucose control – to 7% or ...

Nat Clin Pract Endocrinol Metab. 2006;2(5):240-241. Diabetes occurs when there is an inadequate functional mass of insulin-producing pancreatic β cells. Replacement of β cells by islet ...

The study identified no safety issues, and the HIP-modified islet cells evaded immune responses. “These initial exciting results build upon the extensive preclinical and translational studies of Dr.

PDX-1 is a critically important transcription factor for the insulin promoter, is absent in glucotoxic islets, and, when transfected into glucotoxic ß-cells ... of elevated markers of oxidative ...

Current treatments for T1D, including islet cell transplants ... For Tregs, this means designing CARs that bind only to unique markers on transplanted tissues, ensuring precise immune protection.