ADP is directly detected by a specific monoclonal antibody labeled with europium cryptate and correlates closely with the amount of phosphorylated substrate in a kinase assay. Here we describe a ...

A universal kinase platform HTRF KinEASE screenings limit assay development time and are easily miniaturizable as well as flexible, meaning the assay can be performed under a wide range of kinase ...

With over 15 years of experience in kinase drug discovery, DiscoverX offers the largest collection of nearly 500 biochemical and cell-based kinase assays. KINOMEscan® technology, our novel kinase ...

The conformation of the ATM kinase domain is most similar to the inactive states of other PIKKs ... We evaluate the importance of these structural findings with mutagenesis and biochemical assays.

Triple-negative breast cancer (TNBC) is the subtype of breast cancer that is the hardest to treat. TNBC patients account for ...

Addition Of Reagent,Aptamer,Au Electrode,Changes In Frequency,Detection Process,Electrochemical Impedance Spectroscopy,Electrochemical Measurements,Electron Transfer ...

Methods The kinase selectivity of TAS5315 was evaluated in a series of biochemical assays. The expression of CD69, a lymphocyte activation marker, stimulated by anti-IgM in the mouse splenic B cells ...

Background Tyrosine kinase 2 (Tyk2) is a member of the JAK family that phosphorylates STAT proteins ... Target engagement was assessed by an ex vivo assay, IL-12 and IL-18 induced IFNγ production.