In humans, many leptin deficiency syndromes are responsive to leptin replacement therapy. As leptin is involved in numerous pathways, the effects of too little leptin are widespread (including ...

Although rare in humans, leptin mutations in mice result in leptin deficiency and lead to early onset obesity, hyperphagia, and hypothalamic hypogonadism. Unlike leptin deficient mice, humans ...

Vitamin D deficiency can be blamed for it. As per study published in The Journal of Steroid Biochemistry and Molecular Biology, Vitamin D is involved in regulating leptin, the appetite regulating ...

The authors conclude that congenital leptin-receptor deficiency should be considered in the differential diagnosis of all patients with early-onset obesity and hyperphagia (in the absence of ...

deficiency or leptin receptor (LEPR) deficiency in 2020. The FDA’s original approvals for setmelanotide were for children and adults aged 6 years and older. The new indication expands the FDA ...

or pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency. Previously, the treatment had been approved for patients aged 6 years ...

Results from the VENTURE trial showed significant reductions in weight and hunger among younger patients treated with setmelanotide.