The lymphatic circulation is also a key player in disease processes such as cancer metastasis ... FGF-2 stimulates both lymphangiogenesis and angiogenesis. FGF-2 upregulates VEGF-C expression ...

resulting in LN lymphangiogenesis and the migration of DCs to the nodes. Increased LN lymphangiogenesis is prevented by the systemic administration of VEGFR-2-neutralizing antibody, suggesting a ...