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Nature Methods | 单细胞研究的新突破:iFlpMosaics如何精准解码基因功能?
引言在生命科学研究中,探究基因的功能是解码生命奥秘的核心任务之一。然而,这项工作往往面临一个关键挑战:如何精准地比较携带突变基因的细胞与正常细胞的生物学差异。在传统研究中,研究人员通常通过独立的实验对象(如不同的实验动物)进行比较,然而,这种方法不可避免地受到外部因素如环境、表观遗传改变及组织微环境 ...
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